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Purpose Better understanding of the molecular mechanisms of metastasis—the major cause of death in osteosarcoma (OS)—is a key for the development of more effective metastasis-suppressive therapy. Here, we investigated the biological relevance of the CXCL12/CXCR4 axis in OS. Methods We interfered with CXCL12/CXCR4 signaling in CXCR4-expressing human 143-B OS cells through stable expression of CXCL12,...
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