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Purpose
Diffusion‐weighted chemical shift imaging (DW‐CSI) of brain metabolites poses significant challenges associated with the acquisition of spectroscopic data in the presence of strong diffusion weighting gradients. We present a reproducible DW‐CSI acquisition and processing scheme that addresses most of the potential sources of instability and provides reproducible and anatomically meaningful...
The dependence of apparent diffusion coefficients (ADCs) of molecules in biological tissues on an acquisition‐specific timescale is a powerful mechanism for studying tissue microstructure. Unlike water, metabolites are confined mainly to intracellular compartments, thus providing higher specificity to tissue microstructure. Compartment‐specific structural and chemical properties may also affect molecule...
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