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Transluminal interventions via so-called natural orifices are gaining interest because they allow operative treatment without any skin incision. We previously described a transoral access for (para-)thyroid resection in pigs. To proceed with the first clinical trials, we evaluated the safety of the new technique.Transoral hemithyroidectomies were performed on 10 living pigs using a special cervicoscope...
Treatment options for secondary hyperparathyroidism were significantly amended with the introduction of cinacalcet and paricalcitol. Limitations of resources in public health systems demand detailed analyses of accruing costs. The aim of this study was to compare the costs of these new treatment modalities to surgery.Patients who underwent initial parathyroidectomy (n = 91) and patients treated with...
Neuroendocrine tumors of the thymus (NETT) are a rare tumor entity of the anterior mediastinum. They belong to the category of foregut carcinoids and are often associated with the multiple endocrine neoplasia type 1 (MEN1) syndrome. Approximately 180 cases have been reported since their first description. NETT reveal an aggressive behavior leading to rapid local invasion and metastatic spread. An...
Background.p16 INK4a alterations are considered to be an early event in pancreatic tumorigenesis and have been described in duct lesions adjacent to pancreatic cancers. This study evaluates whether duct lesions in chronic pancreatitis tissues of patients without pancreatic cancer also harbor genetic alterations in the p16 INK4a tumor-suppressor...
Background. The management of pancreaticoduodenal endocrine tumors (PETs) remains controversial in multiple endocrine neoplasia type 1 (MEN 1). Methods. Twenty-one patients with MEN 1 and PETs were analyzed for outcome of surgery and surveillance with special regard to the genotype based on MEN1 gene mutation analysis. Results. Nine patients had gastrinomas, 5 had nonfunctioning tumors, 4 had insulinomas,...
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