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Background
Malignant pleural mesothelioma (MPM) is characterized by mutations in several genes, including cyclin‐dependent kinase‐inhibitor 2A/p16 in the 9p21 locus, BRCA1‐associated protein 1 (BAP1), and neurofibromatosis type 2 (NF2) in the 22q12 locus. Recent studies indicate that fluorescence in situ hybridization (FISH) detects hemizygous loss of NF2 in tissue specimens of MPM. The authors investigated...
BACKGROUND
Homozygous deletion of 9p21 detected by fluorescence in situ hybridization (FISH) and loss of BRCA1‐associated protein 1 (BAP1) expression detected by immunohistochemistry (IHC) are useful for the differentiation between malignant pleural mesothelioma (MPM) and reactive mesothelial hyperplasia. The authors previously described that IHC expression of the protein product of the methylthioadenosine...
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