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Aims
Lymphoepithelioma‐like carcinomas (LELCs) are uncommon epithelial cancers characteristically showing two distinct components consisting of malignant epithelial cells and prominent dense lymphoid infiltrate. Hepatic LELCs consist of two types, the lymphoepithelioma‐like hepatocellular carcinoma and lymphoepithelioma‐like cholangiocarcinoma (LEL‐CCA), with the latter being strongly associated...
Aims
The scirrhous variant of hepatocellular carcinoma (S‐HCC) and fibrolamellar HCC (FL‐HCC) are less common subtypes of HCC that are characterized by abundant fibrous stroma. Here, we aimed to investigate differences in the tumour microenvironment and the tumour epithelial cell characteristics of S‐HCC and FL‐HCC.
Methods and results
Whole tissue sections of 17 S‐HCCs and 9 FL‐HCCs were subjected...
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