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We previously showed that murine Langerhans cells (LC) express CD40 ligand (CD40L). In this study, we further investigated the function of CD40L on LC using agonistic antibodies and CD40L knockout (KO) mice. Signaling through CD40L decreased CD80 expression on LC 48h after stimulation and the decrease was more remarkable in the presence of interferon-γ (IFN-γ). Signaling through CD40 enhanced the...
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