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GR103545 is a potent and selective kappa-opioid receptor agonist. Previous studies in non-human primates demonstrated favorable properties of [11C]GR103545 as a positron emission tomography tracer for in vivo imaging of cerebral kappa-opioid receptor. Nonetheless, advancement of [11C]GR103545 to imaging studies in humans was hampered by difficulties of its multiple-step radiosynthesis, which produces...
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