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In this study, we analyzed coevolution between Staphylococcus aureus strain SA003 and its lytic bacteriophage ΦSA012 to obtain novel insights into S. aureus–its phage interaction. Coevolution was induced in batch co-cultures, repeated 46 times with serial transfer. Although five replicate co-cultures ultimately resulted in bacterial survival and phage extinction, SA003 and ΦSA012 stably coexisted...
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