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Rationale Sedation, dependence, and abuse liability limit the use of non-selective γ-aminobutyric acid (GABAA) receptor positive modulators for the treatment of anxiety. AZD7325 and AZD6280 are novel, subtype-selective GABAAα2,3 receptor positive modulators with limited sedative effects. Objectives The current study aimed to confirm target engagement at GABAA receptors by AZD7325 and AZD6280 in...
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