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Several examples have shown that C3d3, when fused to a corresponding antigen, had a strong adjuvant effect on certain specific antibody production. In a previous study, we attempted to prove that this was the case of the human chorionic gonadotrophin β chain (hCGβ)-induced immunity following DNA vaccination. However, we found that C3d3 when fused to hCGβ inhibited rather than enhanced the antigen-specific...
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