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The R- and S-enantiomers of racemic 3,4-methylenedioxymethamphetamine (MDMA) exhibit different dose–concentration curves. In plasma, S-MDMA was eliminated at a higher rate, most likely due to stereoselective metabolism. Similar data were shown in various in vitro experiments. The aim of the present study was the in vivo investigation of stereoselective elimination of MDMA's phase I and phase II metabolites...
3,4‐Methylenedioxymethamphetamine (MDMA) is a racemic drug of abuse and its R‐ and S‐enantiomers are known to differ in their dose‐response curve. The S‐enantiomer was shown to be eliminated at a higher rate than the R‐enantiomer most likely explained by stereoselective metabolism that was observed in various in vitro experiments. The aim of this work was the development and validation of methods...
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