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A membrane receptor, Fas (CD95), and its ligand FasL have been considered as key players in diabetes pathogenesis. They are known to mediate interactions between β cells and cytotoxic T cells, which results in apoptotic cell death. We hypothesized that the interruption of Fas–FasL interactions by suppressing Fas expression in β cells would affect the development of diabetes. The effect of Fas-silencing...
A cardiomyocyte-targeted Fas siRNA delivery system was developed using prostaglandin E 2 (PGE 2 )-modified siRNA polyplexes formed by a reducible poly(amido amine) to inhibit cardiomyocyte apoptosis. PGE 2 , which was used as a specific ligand for cardiomyocyte targeting, was conjugated to the terminal-end of the sense siRNA (PGE 2 -siRNA). The reducible cationic copolymer,...
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