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Nanotherapeutics for Spinal Cord Injury
In article number 2102102, Zhizhong Li, Tianfeng Chen, and co‐workers design a polymer‐based nano drug delivery system conjugating with MMPs‐responsive molecule to target the injury site, regulate the polarization of macrophages and exert neuroprotective effects to promote locomotor recovery.
Neuroinflammation is critically involved in the repair of spinal cord injury (SCI), and macrophages associated with inflammation propel the degeneration or recovery in the pathological process. Currently, efforts have been focused on obtaining efficient therapeutic anti‐inflammatory drugs to treat SCI. However, these drugs are still unable to penetrate the blood spinal cord barrier and lack the ability...
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