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The coevolution of neurons and their supporting glia to the highly specialized axon-myelin unit included the recruitment of proteolipids as neuronal glycoproteins (DMβ, DMγ) or myelin proteins (DMα/PLP/DM20). Consistent with a genome duplication at the root of teleosts, we identified three proteolipid pairs in zebrafish, termed DMα1 and DMα2, DMβ1 and DMβ2, DMγ1 and DMγ2. The paralogous amino acid...
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