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The pro-apoptotic protein Bax is instable in many cancer cells but the mechanism of Bax degradation remains unclear. Four different lengths of deductive Bax degradation sensitive (BDS) sequences within BH3–BH1 region, BDS-1 (Bax 67–124), BDS-3 (Bax 74–107), BDS-5 (Bax 67–107), and BDS-7 (Bax 74–124), were tested for the susceptibility to ubiquitin-dependent degradation. Both BDS-1 and BDS-7 which...
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