Search results for: Zhisong He

Items from 1 to 20 out of 33 results

article

Magnetic resonance imaging features of prostatic stromal tumour of uncertain malignant potential

Yi Liu, Jingyun Wu, Qi Shen, Derun Li, more

Journal of Medical Imaging and Radiation Oncology > 66 > 8 > 1065 - 1072

Introduction Prostatic stromal tumours of uncertain malignant potential (STUMPs) are rare prostate tumours. The purpose of this study was to investigate the magnetic resonance imaging features of STUMPs. Methods A total of 12 patients with STUMP confirmed with pathology who underwent MRI from 2012 to 2020 were retrospectively reviewed. Pathological characteristics including histopathology and immunohistochemistry...

article

Special issue “The advance of solid tumor research in China”: Presurgical therapy in the management of local retroperitoneal recurrence of renal cell carcinoma after radical nephrectomy

Yueming Wang, Jiwei Huang, Cuijian Zhang, Xiaoyi Hu, more

International Journal of Cancer > 152 > 1 > 24 - 30

Local retroperitoneal recurrence (RPR) after radical nephrectomy (RN) is rare in patients with renal cell carcinoma (RCC); however, it is associated with poor prognosis and lacks standard treatment. Our study aimed to assess oncological outcomes and prognostic factors of patients that underwent targeted therapy for RPR after RN, and to evaluate the role of presurgical targeted therapy in this context...

article

Morphologic changes after bladder neck intussusception in laparoscopic radical prostatectomy contribute to early postoperative continence

Lin Yao, Yuke Chen, He Wang, Wei Yu, more

International Urology and Nephrology > 2019 > 51 > 7 > 1157-1165

Purpose To explore the mechanism and efficacy of the modified bladder neck intussusception in laparoscopic radical prostatectomy (LSRP) on postoperative early continence. Methods We prospectively collected clinical information of prostate cancer patients who underwent LSRP with modified bladder neck intussusception (n = 10) and non-intussusception (n = 10). At postoperative 1 month, the prostate-specific...

article

Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

Ding Peng, Guangzhe Ge, Yanqing Gong, Yonghao Zhan, more

Clinical Epigenetics > 2018 > 10 > 1 > 1-13

Background 5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases. The loss of 5hmC has been identified as a hallmark of most types of cancer and is related to tumorigenesis and progression. However, the role of 5hmC in bladder cancer is seldom investigated. Vitamin C was recently reported to induce the...

article

Identification and characterization of functional modules reflecting transcriptome transition during human neuron maturation

Zhisong He, Qianhui Yu

BMC Genomics > 2018 > 19 > 1 > 1-11

Background Neuron maturation is a critical process in neurogenesis, during which neurons gain their morphological, electrophysiological and molecular characteristics for their functions as the central components of the nervous system. Results To better understand the molecular changes during this process, we combined the protein-protein interaction network and public single cell RNA-seq data of...

article

Ileal Ureter Replacement Combined With Boari Flap-Psoas Hitch to Treat Full-Length Ureteral Defects: Technique and Initial Experience

Wenlong Zhong, Yicong Du, Kunlin Yang, Steven Meng, more

Urology > 2017 > 108 > C > 201-206

To evaluate the feasibility of ileal ureter replacement combined with Boari flap-psoas hitch procedure for the management of full-length ureteral defects (>20 cm).Three patients diagnosed with full-length ureteral defect were treated with our technique performed by a single surgeon between January 2015 to January 2016. All the patients had borderline renal function preoperatively. In each case,...

article

Prognostic significance of PD-L1 expression on tumor cells and tumor-infiltrating mononuclear cells in upper tract urothelial carcinoma

Bo Zhang, Wei Yu, Xueru Feng, Zheng Zhao, more

Medical Oncology > 2017 > 34 > 5 > 1-9

Immunotherapy targeting the programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) pathway has shown promising results in several malignancies. However, the prognostic significance of PD-L1 expression remains unknown in patients with upper tract urothelial carcinoma (UTUC). This study aimed to evaluate PD-L1 expression and its association with clinicopathological characteristics and oncological outcomes...

article

Pretreatment serum pseudocholinesterase level as a novel prognostic biomarker for upper tract urothelial carcinoma

Bo Zhang, Cheng Shen, Jie Jin, Yi Song, more

International Urology and Nephrology > 2016 > 48 > 12 > 1993-1999

Purpose Pretreatment serum pseudocholinesterase (PChE) has been reported to be a prognostic predictor in several cancers. However, the prognostic significance of serum PChE level in patients with upper tract urothelial carcinoma (UTUC) remains unknown. Methods A total of 180 patients who underwent radical nephroureterectomy (RNU) for UTUC were included in this retrospective analysis. The associations...

article

Natural history of renal cell carcinoma: An immunohistochemical analysis of growth rate in patients with delayed treatment

Lei Zhang, Lin Yao, Xuesong Li, Michael A.S. Jewett, more

Journal of the Formosan Medical Association > 2016 > 115 > 6 > 463-469

To investigate the natural history of renal cell carcinoma (RCC) with delayed treatment and to immunohistochemically analyze the correlation between some biomarkers and the growth rate of RCC.We reviewed our institutional databases to identify renal tumors which were confirmed to be RCC by delayed surgical treatment after at least 12 months of active surveillance (AS). Growth rate was defined as the...

article

Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder

Chi-Ya Kao, Zhisong He, Anthony S. Zannas, Oliver Hahn, more

Journal of Psychiatric Research > 2016 > 76 > C > 74-83

Despite intense research efforts the molecular mechanisms affecting stress-vulnerable brain regions in posttraumatic stress disorder (PTSD) remain elusive. In the current study we have applied global transcriptomic profiling to a PTSD mouse model induced by foot shock fear conditioning. We compared the transcriptomes of prelimbic cortex, anterior cingulate cortex (ACC), basolateral amygdala, central...

article

Comparison between completely and traditionally retroperitoneoscopic nephroureterectomy for upper tract urothelial cancer

Lin Yao, Kunlin Yang, Xuesong Li, Zheng Zhang, more

World Journal of Surgical Oncology > 2016 > 14 > 1 > 1-7

Background To evaluate the safety and efficacy of the completely retroperitoneoscopic nephroureterectomy (CRNU), a retrospectively comparative study between completely and traditionally retroperitoneoscopic nephroureterectomy (TRNU) was done in a single center. Methods From January 2014 to December 2014, 107 patients with upper tract urothelial cancer (UTUC) underwent CRNU. The kidney was retroperitoneoscopically...

article

The prognostic impact of squamous and glandular differentiation for upper tract urothelial carcinoma patients after radical nephroureterectomy

Qi Tang, Gengyan Xiong, Xuesong Li, Dong Fang, more

World Journal of Urology > 2016 > 34 > 6 > 871-877

Purpose To evaluate the association between tumor squamous and/or glandular differentiation and tumor biological characteristics and to validate the impact of these histologic variants on oncologic outcomes of UTUC patients. Methods We retrospectively analyzed the data of 687 UTUC patients who underwent radical nephroureterectomy in our institute, from Aug 1, 1999, to Dec 31, 2011. All pathologic...

article

MP2-01 CONTRALATERAL UPPER TRACT UROTHELIAL CARCINOMA AFTER NEPHROURETERECTOMY: THE PREDICTIVE ROLE OF METHYLATION STATUS

Lei Zhang, Gengyan Xiong, Dong Fang, Xuesong Li, more

The Journal of Urology > 2015 > 193 > 4 Supplement > e9-e10

article

Presence of Concomitant Non-muscle-invasive Bladder Cancer in Chinese Patients with Upper Tract Urothelial Carcinoma: Risk Factors, Characteristics, and Predictive Value

Dong Fang, Lei Zhang, Xuesong Li, Wei Yu, more

Annals of Surgical Oncology > 2015 > 22 > 8 > 2789-2798

Purpose To explore the characteristics, predictive risk factors, and prognostic effect of concomitant non-muscle-invasive bladder cancer (NMIBC) in patients with upper tract urothelial carcinoma (UTUC). Methods We evaluated 727 consecutive UTUC patients treated with radical resection between 2000 and 2012 in a high-volume center of China. Preoperative cystoscopy was performed in all patients...

article

A Modified Suture Technique for Transperitoneal Laparoscopic Dismembered Pyeloplasty of Pelviureteric Junction Obstruction

Kunlin Yang, Lin Yao, Xuesong Li, Cuijian Zhang, more

Urology > 2015 > 85 > 1 > 263-267

To describe a modified suture technique for transperitoneal laparoscopic dismembered pyeloplasty (TPLDP) that can be consistently replicated.Between June 2010 and April 2014, 21 men and 7 women with primary pelviureteric junction obstruction underwent our modified TPLDP suture technique performed by the same surgeon. In our method, the dismembering should be performed after performing half of anastomosis...

article

Laparoscopic total pelvic exenteration for pelvic malignancies: the technique and short-time outcome of 11 cases

Kunlin Yang, Lin Cai, Lin Yao, Zheng Zhang, more

World Journal of Surgical Oncology > 2015 > 13 > 1 > 1-9

Background Previous reports about laparoscopic total pelvic exenteration (LTPE) are still limited. In the present study, we described our single-center experience of the initial 11 cases. Methods Between April 2011 and September 2015, eight males and three females diagnosed as pelvic malignancies underwent LTPE by the same operation team. We retrospectively collected all cases’ parameters about...

article

Evaluating intra- and inter-individual variation in the human placental transcriptome

David A Hughes, Martin Kircher, Zhisong He, Song Guo, more

Genome Biology > 2015 > 16 > 1 > 1-18

Background Gene expression variation is a phenotypic trait of particular interest as it represents the initial link between genotype and other phenotypes. Analyzing how such variation apportions among and within groups allows for the evaluation of how genetic and environmental factors influence such traits. It also provides opportunities to identify genes and pathways that may have been influenced...

article

Contralateral upper tract urothelial carcinoma after nephroureterectomy: the predictive role of DNA methylation

Lei Zhang, Gengyan Xiong, Dong Fang, Xuesong Li, more

Journal of Experimental & Clinical Cancer Research > 2015 > 34 > 1 > 1-11

Background Aberrant methylation of genes is one of the most common epigenetic modifications involved in the development of urothelial carcinoma. However, it is unknown the predictive role of methylation to contralateral new upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). We retrospectively investigated the predictive role of DNA methylation and other clinicopathological...

article

Prevalence and factors associated with baseline chronic kidney disease in China: A 10-year study of 785 upper urinary tract urothelial carcinoma patients

Gengyan Xiong, Xiaopeng Chen, Xuesong Li, Dong Fang, more

Journal of the Formosan Medical Association > 2014 > 113 > 8 > 521-526

There is relatively little literature on prevalence of chronic kidney disease (CKD) prior to surgery in patients with upper urinary tract urothelial carcinoma (UTUC). We evaluated the prevalence and clinical associated factors of baseline CKD in patients with UTUC.There were 785 patients with a pathologic diagnosis of UTUC from January 2002 to December 2011 who were analyzed in this study. Estimated...

article

Renal Cell Carcinoma With Infrahepatic Vena Caval Tumor Thrombus Treated With a Novel Combined Retroperitoneal and Transperitoneal Pure Laparoscopic Procedure

Qi Tang, Tianyu Wang, Xuesong Li, Zheng Zhang, more

Urology > 2014 > 83 > 5 > e9-e10

A 61-year-old male patient presented with intermittent gross hematuria. A right renal mass with infrahepatic vena caval tumor thrombus was found using magnetic resonance imaging. We undertook a novel combined retroperitoneal and transperitoneal pure laparoscopic nephrectomy with vena caval thrombectomy for this patient. The patient recovered well after surgery and discharged on day 6. A clear cell...

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INFONA - science communication portal

Search results for: Zhisong He

Magnetic resonance imaging features of prostatic stromal tumour of uncertain malignant potential

Special issue “The advance of solid tumor research in China”: Presurgical therapy in the management of local retroperitoneal recurrence of renal cell carcinoma after radical nephrectomy

Morphologic changes after bladder neck intussusception in laparoscopic radical prostatectomy contribute to early postoperative continence

Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

Identification and characterization of functional modules reflecting transcriptome transition during human neuron maturation

Ileal Ureter Replacement Combined With Boari Flap-Psoas Hitch to Treat Full-Length Ureteral Defects: Technique and Initial Experience

Prognostic significance of PD-L1 expression on tumor cells and tumor-infiltrating mononuclear cells in upper tract urothelial carcinoma

Pretreatment serum pseudocholinesterase level as a novel prognostic biomarker for upper tract urothelial carcinoma

Natural history of renal cell carcinoma: An immunohistochemical analysis of growth rate in patients with delayed treatment

Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder

Comparison between completely and traditionally retroperitoneoscopic nephroureterectomy for upper tract urothelial cancer

The prognostic impact of squamous and glandular differentiation for upper tract urothelial carcinoma patients after radical nephroureterectomy

MP2-01 CONTRALATERAL UPPER TRACT UROTHELIAL CARCINOMA AFTER NEPHROURETERECTOMY: THE PREDICTIVE ROLE OF METHYLATION STATUS

Presence of Concomitant Non-muscle-invasive Bladder Cancer in Chinese Patients with Upper Tract Urothelial Carcinoma: Risk Factors, Characteristics, and Predictive Value

A Modified Suture Technique for Transperitoneal Laparoscopic Dismembered Pyeloplasty of Pelviureteric Junction Obstruction

Laparoscopic total pelvic exenteration for pelvic malignancies: the technique and short-time outcome of 11 cases

Evaluating intra- and inter-individual variation in the human placental transcriptome

Contralateral upper tract urothelial carcinoma after nephroureterectomy: the predictive role of DNA methylation

Prevalence and factors associated with baseline chronic kidney disease in China: A 10-year study of 785 upper urinary tract urothelial carcinoma patients

Renal Cell Carcinoma With Infrahepatic Vena Caval Tumor Thrombus Treated With a Novel Combined Retroperitoneal and Transperitoneal Pure Laparoscopic Procedure

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