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Most cases of Usher syndrome type II (USH2) are due to mutations in the USH2A gene. There are no effective treatments or ideal animal models for this disease, and the pathological mechanisms of USH2 caused by USH2A mutations are still unknown. Here, we constructed a ush2a knockout (ush2a−/−) zebrafish model using TALEN technology to investigate the molecular pathology of USH2. An early onset auditory...
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