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Background Small interfering RNA (siRNA) can be used to post-transcriptional gene regulation by knocking down targeted genes. In functional genomics, biomedical research and cancer therapeutics, siRNA design is a critical research topic. Various computational algorithms have been developed to select the most effective siRNA, whereas the efficacy prediction accuracy is not so satisfactory. Many existing...
In functional genomics, small interfering RNA (siRNA) can be used to knockdown gene expression. Usually, a target gene has numerous potential siRNAs, but their efficiencies of gene silencing often varies. Thus, for a successful RNA interference (RNAi), selecting the most effective siRNA is a critical step. Despite various computational algorithms have been developed, the efficacy prediction accuracy...
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