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In previous studies, we showed that the recipient spleen 12 h after liver transplantation included highly immunogenic donor passenger leukocytes (PLs) in the nonrejector rat strain combination (Lewis: LEW→Wistar Furth: WF). Furthermore, we noted that giving anti-CD4 mAb to WF recipients at the time of liver grafting prolonged the liver damage due to primary rejection reaction, suggesting that CD4...
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