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NK1.1 + T cells develop and function through interactions with cell surface CD1 complexes. In I-A b mice lacking the invariant chain (Ii) processing enzyme, cathepsin S, NK1.1 + T cell selection and function are impaired. In vitro, thymic dendritic cells (DCs) from cathepsin S -/- mice exhibit defective presentation of the CD1-restricted antigen, α-galactosylceramide...
NKT cells are associated with immunological control of autoimmune disease and cancer and can recognize cell surface mCDld without addition of exogenous antigens. Cellular antigens presented by mCDld have not been identified, although NKT cells can recognize a synthetic glycolipid, α-GalCer. Here we show that after addition of a lipid extract from a tumor cell line, plate-bound mCDld molecules stimulated...
We have characterized the CD1b-mediated presentation pathway for the mycobacterial lipoglycan lipoarabinomannan (LAM) in monocyte-derived antigen-presenting cells. The macrophage mannose receptor (MR) was responsible for uptake of LAM. Antagonism of MR function inhibited both the internalization of LAM and the presentation of this antigen to LAM-reactive T cells. Intracellular MRs were most abundant...
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