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Lack of expression of major histocompatibility complex (MHC) molecules of both classes is frequently noted on tumour cells [1]. It is thought that in this way tumour cells escape immunosurveillance. The genes encoding both classes of MHC molecules are localized on the distal part of chromosome 6 (6p21.3). The class II transactivator (CIITA), encoded by the MHC2TA gene, is essential for transcriptional...
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