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Background and aims
Cannabis is one of the most commonly used substances among adolescents and young adults. Earlier age at cannabis initiation is linked to adverse life outcomes, including multi‐substance use and dependence. This study estimated the heritability of age at first cannabis use and identified associations with genetic variants.
Methods
A twin‐based heritability analysis using 8055...
Although there is evidence that opioid dependence (OD) is heritable, efforts to identify genes contributing to risk for the disorder have been hampered by its complex etiology and variable clinical manifestations. Decomposition of a complex set of opioid users into homogeneous subgroups could enhance genetic analysis. We applied a series of data mining techniques, including multiple correspondence...
Aims To identify and validate homogeneous subtypes of opioid use and related behaviors.
Design Family‐based and case–control genetic studies of opioid and/or cocaine dependence.
Settings Clinical and general community samples from Connecticut, Massachusetts, Pennsylvania and South Carolina.
Participants A total of 4061 individuals (2003 individuals from 835 families and 2058 unrelated individuals)...
Cocaine dependence (CD) is a multifactorial disorder, variable in its manifestations, and heritable. We examined the concurrent validity of homogeneous subgroups of CD as phenotypes for genetic analysis. We applied data reduction methods and an empirical cluster-analytic approach to measures of cocaine use, cocaine-related effects, and cocaine treatment history in 1393 subjects, from 660 small nuclear...
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