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We report a genome-wide association study (GWAS) of nicotine dependence defined on the basis of scores on the Fagerström Test for Nicotine Dependence in European-American (EA) and African-American (AA) populations.Our sample, from the one used in our previous GWAS, included only subjects who had smoked >100 cigarettes lifetime (2114 EA and 2602 AA subjects) and an additional 927 AA and 2003 EA...
The N‐methyl‐D‐aspartate (NMDA) glutamate receptors play important roles in the pathophysiology of substance dependence (SD), but no strong genetic evidence has associated common variants in NMDAR‐related genes to SD. We hypothesized that rare variants (RVs) with minor allele frequency <1% in the NMDAR‐related genes might exert large effects on SD risk. We sequenced 34 544 bp of coding and flanking...
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