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We report various technologies developed in our lab for in vivo Raman spectroscopy and related clinical applications. This includes macroscopic probes and endoscopy catheters that interrogate millimeter-scale tissue volumes for skin and lung cancer detection and a confocal microscopy system for depth-resolved Raman measurements of the skin in vivo.
Ten groups of mice were exposed to 785 nm laser after intratumoral injection of single-wall carbon nanotubes (SWNTs). The temperature within the tumors increased in a light- and drug-dose dependent manner; optimized light and drug dose combinations resulted in eradication of skin tumors. SWNTs persisted within the tumor tissue for months.
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