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We have compared differentiation ability of glioblastoma cells with differentiation ability of neural progenitors. An effi cient differentiation arrest was observed in all cell lines isolated from glioblastomas in contrast to normal neural progenitors. However, cells isolated from six glioblastomas showed features of early stages of neural differentiation. Moreover, the cells derived from a majority...
The aim of our study was to evaluate the frequencies of loss of heterozygosity (LOH) on chromosomes 1p, 10q, and 19q in gliomas and to correlate them with the histological diagnosis and with patient age and gender. We found deletions within chromosome 1p to be significantly associated with the histological subtype of glial tumor (P<0.05); frequency of 1p deletions increased from astrocytoma (0%)...
The aim of our study was to evaluate the frequencies of loss of heterozygosity (LOH) on chromosomes 1p, 10q, and 19q in gliomas and to correlate them with the histological diagnosis and with patient age and gender. We found deletions within chromosome 1p to be significantly associated with the histological subtype of glial tumor (P < 0.05); frequency of 1p deletions increased from astrocytoma (0%)...
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