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Saccharomyces cerevisiae provides an excellent eukary-otic model for biomedical and medicinal research. In this article, yeast was applied in pharmacological studies to identify new targets and mechanisms of action of drugs, as well as pathways involved in drug resistance. The work here presented is focused on two distinct drugs: the traditional anti-malarial quinine, and the paradigmatic anti-cancer...
Quinine is used in the treatment of Plasmodium falciparum severe malaria. However, both the drug’s mode of action and mechanisms of resistance are still poorly understood and subject to debate. In an effort to clarify these questions, we used the yeast Saccharomyces cerevisiae as a model for pharmacological studies with quinine. Following on a previous work that examined the yeast genomic expression...
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