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The non-opioid analgesic dipyrone can trigger life-threatening blood formation disorders. However, it is frequently used, as many patients with coronary artery disease (CAD) rely on non-opioid analgesics to relieve pain.In this study, we investigated the incidence of death, myocardial infarction (MI) or stroke in CAD patients with aspirin and dipyrone comedication as compared to aspirin-alone.We conducted...
Klinische Studien belegen die Bedeutung der Herzfrequenz für die kardiovaskuläre Morbidität und Mortalität. Seit mehr als 50 Jahren wird über selektiv herzfrequenzreduzierende Substanzen nachgedacht. Seit den 80er Jahren ist bekannt, dass If-Ionenkanäle am Sinusknoten für den Automatismus und die Modulation der Herzfrequenz eine entscheidende Rolle spielen. Theoretisch lassen sich mit selektiv herzfrequenzreduzierenden...
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