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Key points
Maternal obesity predisposes to metabolic dysfunction in male and female offspring
Maternal high‐fat diet consumption prior to and throughout pregnancy and lactation accelerates offspring metabolic ageing in a sex‐dependent manner
This study provides evidence for programming‐ageing interactions
Abstract
Human epidemiological studies show that maternal obesity (MO) shortens offspring...
Synapses loss during aging has been related to decreased neuronal excitability and reduced electrophysiological activity in the nervous system, as well as to increased brain damage. Those physiological and biochemical alterations have been related to the oxidative stress increase associated with old age. The main substrate of lipid peroxidation (LPX) in the central and peripheral nervous systems are...
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