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Prostaglandin E receptors (EPs) are the G-protein-coupled receptors (GPCRs) that respond to type E 2 prostaglandin (PGE 2 ). Data has shown that PGE 2 may function as an endogenous anti-inflammatory mediator by suppressing the production of cytokines. However, other studies have demonstrated that PGE 2 , a pro-inflammatory mediator produced by various cell types within...
Genistein (4,5,7-trihydroxyisoflavone), a phytoestrogen with selective estrogen receptor modulator properties, has received a great deal of attention over the last few years because of its potentially preventive roles against cardiovascular diseases. However, the precise molecular mechanisms for this modulation are not fully elucidated. In this study, we investigated (both in vivo and in vitro) the...
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