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Background
Humans with inactivating mutations in growth hormone receptor (GHR) have lower rates of cancer, including prostate cancer. Similarly, mice with inactivating Ghr mutations are protected from prostatic intraepithelial neoplasia in the C3(1)/TAg prostate cancer model. However, gaps in clinical relevance in those models persist. The current study addresses these gaps and the ongoing role of...
Growth hormone receptor knockout mice (GHRKO) are characterized by high insulin sensitivity and extended lifespan. Interestingly, the secretory activity of visceral fat in GHRKO mice is altered, stimulating whole body insulin sensitivity. In this study, we transplanted normal (N) mice with visceral fat pads from GHRKO or N mice to determine the role of visceral fat on the insulin signaling. We found...
A portion of the rat growth hormone receptor (GHR) gene was cloned by PCR. Restriction enzyme digestion and DNA sequence analyses revealed that an exon, exon 8A, encoding the carboxy terminus of the rat serum growth hormone binding protein (GHBP) was located between exons 7 and 8 of the rat GHR gene. Two tandem poly-adenylation (poly A) signals for the GHBP mRNA were found in the 3 -untranslated...
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