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The present study was designed to assess aortic valve morphology and function in mice of advanced age. We also evaluated the potential contribution of bone-marrow-derived cells to the pathogenesis of aortic stenosis.Age-associated valvular degeneration is characterized by lipid accumulation, collagen deposition, and calcification containing smooth muscle-like cells and osteoblast-like cells. Cellular...
The development of transplant arteriosclerosis (TA) is a major limiting factor for long time survival of transplanted organs. The mechanisms remain unknown but undiagnosed rejections eliciting release of growth factors are thought to be involved in accelerating myointimal proliferation. We hypothesized that IGF-I may be a crucial growth factor in this process. Thus, we studied the effect of IGF-I...
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