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We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon‐regulatory factor) C‐terminus creates hyperactive IRF4. When introduced into IRF4‐deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2‐linked IL‐13 production were much less altered.
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