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The hypothalamic neuropeptide melanin-concentrating hormone (MCH) plays a critical role in energy homeostasis. Abundant expression of the MCH receptor is observed outside the hypothalamus, especially in the dorsal and the ventral striatum, raising the possibility that MCH modulates the function of the midbrain dopamine neurons and associated circuitry.The MCH receptor 1 (MCHR1) expression was assessed...
The gastrointestinal-derived hormone peptide YY (PYY) is released from intestinal L-cells post-prandially in proportion to calorie intake, and modulates food intake. Peripheral administration of PYY (3–36) reduces food intake and body weight in rodents and suppresses appetite and food intake in humans. PYY (3–36) is hypothesised to inhibit food intake via activation of the auto-inhibitory...
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