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BackgroundSurvival of vascularized xenografts is dependent on pre‐emptive inhibition of the xenoantibody response against galactosyltransferase knockout (GTKO) porcine organs. Our analysis in multiple GTKO pig‐to‐primate models of xenotransplantation has demonstrated that the anti‐non‐gal‐α‐1,3‐gal (anti‐non‐Gal) xenoantibody response displays limited structural diversity. This allowed our group to...
BackgroundPromising developments in porcine islet xenotransplantation could resolve the donor pancreas shortage for patients with type 1 diabetes. Using α1,3‐galactosyltransferase gene knockout (GTKO) donor pigs with multiple transgenes should extend xenoislet survival via reducing complement activation, thrombus formation, and the requirement for exogenous immune suppression. Studying the xenoantibody...
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