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Postmitotic neurons must survive for the entire life of the organism and be able to respond adaptively to adverse conditions of oxidative and genotoxic stress. Unrepaired DNA damage can trigger apoptosis of neurons which is typically mediated by the ataxia telangiectasia mutated (ATM)–p53 pathway. As in all mammalian cells, telomeres in neurons consist of TTAGGG DNA repeats and several associated...
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