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Iron overload is tightly connected with metabolic disorders. Excess iron in the adipose and its roles in dyslipidemia are of interest to be identified. In acute iron overload mice receiving intraperitoneal injection of 100 mg/kg/day dextran‐iron for 5 days, the epididymis adipose showed a remarkable increase in iron. Serum triglyceride and low‐density lipoprotein cholesterol (LDL‐C) levels were increased...