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Background
Stereotactic body radiotherapy (SBRT) is gaining wider adoption for prostate cancer management but there remain significant toxicity risks when delivering prostate SBRT with standard techniques. Magnetic resonance‐guided daily adaptive SBRT (MRg‐A‐SBRT) offers technological advantages in precision of radiation dose delivery, but the toxicity profile associated with MRg‐A‐SBRT compared...
Background
The aims of this study were to provide data on the safety of head and neck cancer surgery currently being undertaken during the coronavirus disease 2019 (COVID‐19) pandemic.
Methods
This international, observational cohort study comprised 1137 consecutive patients with head and neck cancer undergoing primary surgery with curative intent in 26 countries. Factors associated with severe...
The treatment of patients with cancer who test positive for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses unique challenges. In this commentary, the authors describe the ethical rationale and implementation details for the creation of a novel, multidisciplinary treatment prioritization committee, including physicians, frontline staff, an ethicist, and an infectious disease expert...
Background
Certain patients with intermediate‐risk prostate cancer (PCa) may be appropriate candidates for active surveillance (AS). In the current study, the authors sought to characterize AS use and early mortality outcomes for patients with intermediate‐risk PCa in the United States.
Methods
The novel Surveillance, Epidemiology, and End Results Active Surveillance/Watchful Waiting database identified...
BACKGROUND
Definitive stereotactic body radiotherapy (SBRT) represents an emerging and debated treatment option for patients with prostate cancer, with potential economic savings and reports of short‐term efficacy since 2006. The current study sought to define national trends in definitive prostate SBRT use and determine whether patterns vary by travel distance for treatment.
METHODS
The National...
BACKGROUND
Conservative management of aggressive prostate cancer in the elderly without definitive therapy has been associated with a 10‐year prostate cancer‐specific mortality of approximately 50%. The authors examined the prevalence of definitive therapy in elderly patients with intermediate‐risk or high‐risk disease.
METHODS
411,343 patients who were diagnosed from 2004 through 2012 with intermediate‐risk...
BACKGROUND
Most major cancer organizations seek to reduce sociodemographic disparities in high‐risk cancers partly by increasing access to theoretically high‐quality, academic‐oriented cancer care. The objective of this study was to determine whether academic centers have less sociodemographic treatment disparities than community centers using high‐risk prostate cancer as a test case.
METHODS
The...
BACKGROUNDIn the current study, the authors sought to both characterize the national trends in proton therapy use for prostate cancer and determine the factors associated with receipt of this limited resource, using what to the best of their knowledge is the largest nationwide cancer registry.
METHODSThe National Cancer Data Base was used to identify 187,730 patients diagnosed with nonmetastatic...
BACKGROUNDTo the authors' knowledge, it remains unknown whether race‐based differences in cancer outcomes have changed with time. In the current study, the authors assessed whether racial disparities in cancer‐specific mortality have improved over the last 20 years.
METHODSThe Surveillance, Epidemiology, and End Results program was used to identify 2,713,474 patients diagnosed between 1988 and 2007...
BACKGROUNDIn 1999 and 2000, 2 national guidelines recommended brachytherapy monotherapy (BT) primarily for treatment of low‐risk prostate cancer but not high‐risk prostate cancer. This study examined rates of BT use before and after publication of these guidelines, as compared with 4 other treatment options.
METHODSFrom 1990 to 2011, 8128 men with localized prostate cancer (≤ T3cN0M0) were treated...
BACKGROUNDFew studies have quantified temporal patterns of cause‐specific mortality in contemporary cohorts of men with early‐stage seminoma. Given that several management strategies can be applied in these patients, each resulting in excellent long‐term survival, it is important to evaluate associated long‐term sequelae. In particular, data describing long‐term risks of cardiovascular disease (CVD)...
BACKGROUND:A study was undertaken to determine the impact of prior coronary revascularization (angioplasty, stent, or coronary artery bypass graft) on the risk of all‐cause mortality after neoadjuvant hormonal therapy (HT) for prostate cancer (PC) in men with a history of coronary artery disease (CAD)‐induced congestive heart failure (CHF) or myocardial infarction (MI).
METHODS:Among 7839 men who...
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