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AimsStress urinary incontinence (SUI) is common in post‐menopausal women. The present study therefore examined how aging and estrogen deficiency induced by ovariectomy (OVX) affect the urethral continence mechanism that prevents sneeze‐induced SUI in rats.
MethodsYoung (3 months old) and middle‐aged (12 months old) female rats underwent bilateral OVX or sham operation. Urethral activity was measured...
Glycine is a major inhibitory neurotransmitter in the spinal cord, the concentration of which is regulated by two types of glycine transporters (GlyTs): GlyT1 and GlyT2. We hypothesized that the inhibition of GlyTs could ameliorate bladder overactivity and/or pain sensation in the lower urinary tract.Investigate the effects of GlyT inhibitors on bladder overactivity and pain behavior in rats.Cystometry...
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