Search results for: Franco Roviello

Items from 1 to 20 out of 118 results

article

Is proctoscopy sufficient for the evaluation of colorectal anastomosis prior to ileostomy reversal? A nationwide retrospective analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative group (SICO‐CCN)

Michele Manigrasso, Maurizio Degiuli, Francesco Maione, Pietro Venetucci, more

Aim Several methods for assessing anastomotic integrity have been proposed, but the best is yet to be defined. The aim of this study was to compare the different methods to assess the integrity of colorectal anastomosis prior to ileostomy reversal. Method A retrospective cohort analysis on patients between 1 January 2010 and 31 December 2020 with a defunctioning stoma for middle and low rectal...

article

Anoplasty for anatomical anal stenosis: systematic review of complications and recurrences

Gaetano Gallo, Arcangelo Picciariello, Gian Luca Di Tanna, Patrizia Pelizzo, more

Colorectal Disease > 24 > 12 > 1462 - 1471

Aim The optimal surgical treatment for anatomical anal stenosis (AS) remains to be determined. The aim of this study was to determine the rates of complications and recurrence after anoplasty for anatomical AS and, wherever feasible, compare the outcomes for the various techniques. Method A PROSPERO‐registered systematic review was reported following the Preferred Reporting Items for Systematic...

article

SARS‐CoV‐2 infection and venous thromboembolism after surgery: an international prospective cohort study

COVIDSurg Collaborative, GlobalSurg Collaborative, Dmitri Nepogodiev, Joana FF Simoes, more

Anaesthesia > 77 > 1 > 28 - 39

SARS‐CoV‐2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri‐operative or prior SARS‐CoV‐2 were at further increased risk of venous thromboembolism. We conducted a planned sub‐study and analysis from...

article

Effects of pre‐operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

COVIDSurg Collaborative, GlobalSurg Collaborative, Dmitri Nepogodiev, Joana FF Simoes, more

Anaesthesia > 76 > 11 > 1454 - 1464

We aimed to determine the impact of pre‐operative isolation on postoperative pulmonary complications after elective surgery during the global SARS‐CoV‐2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors...

article

Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study

COVIDSurg Collaborative, GlobalSurg Collaborative, Dmitri Nepogodiev, Joana FF Simoes, more

Anaesthesia > 76 > 6 > 748 - 758

Peri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS‐CoV‐2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre‐operative SARS‐CoV‐2 infection...

article

Cancer networks as a response to COVID pandemic: A framework from the Italian Society of Surgical Oncology

Gaya Spolverato, Angelo Restivo, Giulia Capelli, Raffaele De Luca, more

Journal of Surgical Oncology > 123 > 5 > 1201 - 1203

article

The effect of learning curve on perioperative outcomes of robotic gastrectomy in two western high‐volume centers

Leonardo Solaini, Alessia D'Ignazio, Daniele Marrelli, Luigi Marano, more

The International Journal of Medical Robotics and Computer Assisted Surgery > 17 > 2 > n/a - n/a

Introduction To compare outcomes of robotic gastrectomy (RG) performed during the learning curve (P1) with those after its completion (P2). Methods In this retrospective study, all consecutive RG patients (n = 92) performed between 2008 and 2018 were included. Primary outcome was conversion rate. Results D2 lymphadenectomies were more common in P2 (41, 97.6%) than P1 (41, 82.0%) (p = 0.019)....

article

From digital world to real life: a robotic approach to the esophagogastric junction with a 3D printed model

Luigi Marano, Alessandro Ricci, Vinno Savelli, Luigi Verre, more

BMC Surgery > 2019 > 19 > 1 > 1-6

Background Three-dimensional (3D) printing may represent a useful tool to provide, in surgery, a good representation of surgical scenario before surgery, particularly in complex cases. Recently, such a technology has been utilized to plan operative interventions in spinal, neuronal, and cardiac surgeries, but few data are available in the literature about their role in the upper gastrointestinal surgery...

article

O‐glycan truncation enhances cancer‐related functions of CD44 in gastric cancer

Stefan Mereiter, Álvaro M. Martins, Catarina Gomes, Meritxell Balmaña, more

FEBS Letters > 593 > 13 > 1675 - 1689

CD44 isoforms are often upregulated in gastric cancer and have been associated with increased metastatic potential and poor survival. To evaluate the functional impact of O‐glycan truncation on CD44 we have analysed glyco‐engineered cancer cell models displaying shortened O‐glycans. Here, we demonstrate that induction of aberrant O‐glycan termination through various molecular mechanisms affects CD44...

article

Conversion gastrectomy for stage IV unresectable gastric cancer: a GIRCG retrospective cohort study

Leonardo Solaini, Silvia Ministrini, Maria Bencivenga, Alessia D’Ignazio, more

Gastric Cancer > 2019 > 22 > 6 > 1285-1293

Background The aim of this study is to report the experience with conversion surgery from six Gruppo Italiano Ricerca Cancro Gastrico (GIRCG) centers, focusing our analysis on factors affecting survival and the risk of recurrence. Methods A retrospective, multicenter cohort study was performed in patients who had undergone conversion gastrectomy between 2005 and 2017. Data were extracted from a...

article

Detection of post-translational modifications using solid-phase proximity ligation assay

Felipe Marques Souza de Oliveira, Stefan Mereiter, Peter Lönn, Benjamin Siart, more

New Biotechnology > 2018 > 45 > C > 51-59

Post-translational modifications (PTMs) regulate protein activities to help orchestrate and fine-tune cellular processes. Dysregulation of PTMs is often related with disorders and malignancies, and may serve as a precise biomarker of disease. Developing sensitive tools to measure and monitor low-abundant PTMs in tissue lysates or serum will be instrumental for opening up new PTM-based diagnostic avenues...

article

The Cholegas trial: long-term results of prophylactic cholecystectomy during gastrectomy for cancer—a randomized-controlled trial

Lapo Bencini, Alberto Marchet, Sergio Alfieri, Fausto Rosa, more

Gastric Cancer > 2019 > 22 > 3 > 632-639

Background The incidence of cholelithiasis has been shown to be higher for patients after gastrectomy than for the general population, due to vagal branch damage and gastrointestinal reconstruction. The aim of this trial was to evaluate the need for routine concomitant prophylactic cholecystectomy (PC) during gastrectomy for cancer. Methods A multicenter, randomized, controlled trial was conducted...

article

Mining the acidic serum proteome utilizing off-gel isoelectric focusing and label free quantitative liquid chromatography mass spectrometry

Josh Smith, Gavin Davey, Karol Polom, Franco Roviello, more

Journal of Chromatography A > 2018 > 1566 > C > 32-43

Serum remains an attractive source for the discovery of disease related biomarkers due to its intimate interaction with the majority of tissues within the body. The dynamic range of proteins present within serum has long complicated the ability to detect low level tissue leakage proteins that offer more promise as potential biomarkers due to their higher degree of specificity. Depletion strategies,...

article

An aggressive early gastric cancer: Kodama's PenA type

Paolo Morgagni, Leonardo Solaini, Luca Saragoni, Maria Bencivenga, more

European Journal of Surgical Oncology (EJSO) > 2018 > 44 > 8 > 1186-1190

To investigate the role of Kodama PenA subtype in influencing survival in patients with early gastric cancer (EGC).All patients surgically treated for EGC at 7 Italian centers (Forlì, Varese, Siena, Verona, Milan, Rome and Perugia) belonging to the Italian Research Group for Gastric Cancer (GIRCG) from January 1982 and December 2009 were included.PenA patients were 230 (21.5%) while other types were...

article

Number of lymph nodes assessed has no prognostic impact in node-negative rectal cancers after neoadjuvant therapy. Results of the “Italian Society of Surgical Oncology (S.I.C.O.) Colorectal Cancer Network” (SICO-CCN) multicentre collaborative study

Maurizio Degiuli, Simone Arolfo, Andrea Evangelista, Laura Lorenzon, more

European Journal of Surgical Oncology (EJSO) > 2018 > 44 > 8 > 1233-1240

We retrospectively investigated the impact of number or complete absence of nodes retrieved on survival of patients with rectal cancer (RC) treated with neoadjuvant radiation-therapy (NAT).All patients with RC treated with NAT followed by curative surgery from 2000 to 2014 in 14 Italian referral Centres for Colorectal Surgery were enrolled. Information about number of nodes harvested, node ratio,...

article

Hereditary diffuse gastric cancer: how to look for and how to manage it

Karol Polom, Daniele Marrelli, Alessia D’Ignazio, Franco Roviello

Updates in Surgery > 2018 > 70 > 2 > 161-166

With a current molecular revolution, hereditary gastric cancer represents a small group of patients that require a special multidisciplinary treatment. Surgeons being a member of the multidisciplinary teams are an important part of the diagnosis, treatment and follow-up of these patients. The prophylactic nature of the gastrectomy with all different problems associated with this procedure need to...

article

International consensus on a complications list after gastrectomy for cancer

Gian Luca Baiocchi, Simone Giacopuzzi, Daniele Marrelli, Daniel Reim, more

Gastric Cancer > 2019 > 22 > 1 > 172-189

Background Perioperative complications can affect outcomes after gastrectomy for cancer, with high mortality and morbidity rates ranging between 10 and 40%. The absence of a standardized system for recording complications generates wide variation in evaluating their impacts on outcomes and hinders proposals of quality-improvement projects. The aim of this study was to provide a list of defined gastrectomy...

article

Clinical impact of molecular classifications in gastric cancer

Daniele Marrelli, Karol Polom, Alessandro Neri, Franco Roviello

Updates in Surgery > 2018 > 70 > 2 > 225-232

Treatment options to gastric cancer (GC) have been changing in recent years from a standard to a tailored approach. Different individualized procedures can range from endoscopic resection, D2 with open or minimally invasive approach, to neo-adjuvant therapy followed by extended surgery. In more advanced stages, a combined approach with the inclusion of intraperitoneal chemo-hyperthermia (HIPEC) may...

article

Synchronous metastatic gastric cancer-molecular background and clinical implications with special attention to mismatch repair deficiency

Karol Polom, Christine Böger, Elizabeth Smyth, Daniele Marrelli, more

European Journal of Surgical Oncology (EJSO) > 2018 > 44 > 5 > 626-631

Current guidelines recommend that metastatic gastric cancer should not be treated with surgery unless this is required for symptom control. We hypothesized that patients with mismatch repair deficiency (MMRd) gastric cancer and metastatic disease detected at the timepoint of surgical resection would have superior survival compared to patients with MMRd cancers in the same setting.Clinicopathological...

article

The pattern of lymph node metastases in microsatellite unstable gastric cancer

Karol Polom, Daniele Marrelli, Valeria Pascale, Francesco Ferrara, more

European Journal of Surgical Oncology (EJSO) > 2017 > 43 > 12 > 2341-2348

Microsatellite instability (MSI) is one of the new groups of molecular divisions of gastric cancer (GC). The aim of this study was to investigate the pattern of lymph node metastasis according to MSI status.MSI analysis of 361 GC patients with information about lymph node stations was performed using 5 quasimonomorphic mononucleotide repeats. The metastasis rates for each lymphatic station was analyzed,...

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INFONA - science communication portal

Search results for: Franco Roviello

Is proctoscopy sufficient for the evaluation of colorectal anastomosis prior to ileostomy reversal? A nationwide retrospective analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative group (SICO‐CCN)

Anoplasty for anatomical anal stenosis: systematic review of complications and recurrences

SARS‐CoV‐2 infection and venous thromboembolism after surgery: an international prospective cohort study

Effects of pre‐operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study

Cancer networks as a response to COVID pandemic: A framework from the Italian Society of Surgical Oncology

The effect of learning curve on perioperative outcomes of robotic gastrectomy in two western high‐volume centers

From digital world to real life: a robotic approach to the esophagogastric junction with a 3D printed model

O‐glycan truncation enhances cancer‐related functions of CD44 in gastric cancer

Conversion gastrectomy for stage IV unresectable gastric cancer: a GIRCG retrospective cohort study

Detection of post-translational modifications using solid-phase proximity ligation assay

The Cholegas trial: long-term results of prophylactic cholecystectomy during gastrectomy for cancer—a randomized-controlled trial

Mining the acidic serum proteome utilizing off-gel isoelectric focusing and label free quantitative liquid chromatography mass spectrometry

An aggressive early gastric cancer: Kodama's PenA type

Number of lymph nodes assessed has no prognostic impact in node-negative rectal cancers after neoadjuvant therapy. Results of the “Italian Society of Surgical Oncology (S.I.C.O.) Colorectal Cancer Network” (SICO-CCN) multicentre collaborative study

Hereditary diffuse gastric cancer: how to look for and how to manage it

International consensus on a complications list after gastrectomy for cancer

Clinical impact of molecular classifications in gastric cancer

Synchronous metastatic gastric cancer-molecular background and clinical implications with special attention to mismatch repair deficiency

The pattern of lymph node metastases in microsatellite unstable gastric cancer

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