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The crystal structure of a binary complex of human antithrombin with a peptide of the same sequence as its reactive loop (P 14 -P 3 ) has been determined at 2.9 A. The peptide binds as the middle strand s4A in the A β-sheet, homologously to that of the reactive loop in the latent and cleaved forms of antithrombin. Peptide binding results in the complete expulsion of the hinge...
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