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In the primary analysis of the phase III OlympiAD trial, olaparib significantly prolonged progression‐free survival (PFS) vs chemotherapy treatment of physician's choice (TPC) in patients with germline BRCA‐mutated (gBRCAm), HER2‐negative metastatic breast cancer (mBC). We report subgroup analyses for the final analysis at a median OS follow‐up of 18.9 months (olaparib) and 15.5 months (TPC). Patients...
BACKGROUND
In postoperative patients with breast cancer, the combination of an anthracycline and cyclophosphamide (AC) followed by a taxane is a standard regimen. In the current study, the authors examined whether AC could be safely omitted, and compared the effectiveness of paclitaxel versus docetaxel.
METHODS
Female postoperative patients with axillary lymph node‐positive breast cancer were eligible...
BACKGROUND:The increasing costs associated with large‐scale adjuvant trials mean that the prognostic value of biologic markers is increasingly important. The expression of nuclear antigen Ki‐67, a marker of cell proliferation, has been correlated with treatment efficacy and is being investigated for its value as a predictive marker of therapeutic response. In the current study, the authors explored...
BACKGROUND:In this study, the authors evaluated the effect of denosumab versus zoledronic acid (ZA) on pain in patients with advanced breast cancer and bone metastases.
METHODS:The prevention of pain, reduction in pain interference with daily life activities, and the proportion of patients requiring strong opioid analgesics were assessed in a randomized, double‐blind, double‐dummy phase 3 study comparing...
Aromatase inhibitor shows efficacy for hormone receptor positive postmenopausal breast cancer. We evaluated the activity of 24 weeks of aromatase inhibition with exemestane for primary breast cancer in a neoadjuvant setting. Patients with stage II/IIIA invasive breast cancer with estrogen receptor (ER) and/or progesterone receptor (PgR)‐positive status were eligible. Primary endpoints were objective...
BACKGROUND:The 21‐gene signature has been intensively studied and incorporated into major guidelines for treatment decision in early breast caner. However, it remains to be examined whether this system is applicable to Asian populations.
METHODS:The authors collected 325 tumor tissues from estrogen receptor (ER)‐positive primary breast cancer patients who had undergone surgery and were treated with...
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