Wyniki wyszukiwania dla: Philip Howard

Pozycje od 1 do 20 spośród 21 wyników

Poprzednia

Następna

artykuł

Antimicrobial stewardship effectiveness on rationalizing the use of last line of antibiotics in a short period with limited human resources: a single centre cohort study

Darija Kuruc Poje, Vesna Mađarić, Vlatka Janeš Poje, Domagoj Kifer, więcej

BMC Research Notes > 2019 > 12 > 1 > 1-6

Objective Antibiotics reserve (ARs) are given as a last line of treatment when other antibiotics are no longer effective. Rising threat of antimicrobial resistance makes growing use of ARs a real problem to patient safety. A single centre interventional cohort study was conducted in order to measure impact on clinical outcomes of A-team programme with limited human resources in a short period. A-team...

artykuł

Organization and training at national level of antimicrobial stewardship and infection control activities in Europe: an ESCMID cross-sectional survey

Alberto Enrico Maraolo, David S. Y. Ong, Cansu Cimen, Philip Howard, więcej

European Journal of Clinical Microbiology & Infectious Diseases > 2019 > 38 > 11 > 2061-2068

Antimicrobial stewardship (AMS) and Infection prevention and control (IPC) are two key complementary strategies that combat development and spread of antimicrobial resistance. The ESGAP (ESCMID Study Group for AMS), EUCIC (European Committee on Infection Control) and TAE (Trainee Association of ESCMID) investigated how AMS and IPC activities and training are organized, if present, at national level...

artykuł

Effects of control interventions on Clostridium difficile infection in England: an observational study

Kate E Dingle, Xavier Didelot, T Phuong Quan, David W Eyre, więcej

The Lancet Infectious Diseases > 2017 > 17 > 4 > 411-421

The control of Clostridium difficile infections is an international clinical challenge. The incidence of C difficile in England declined by roughly 80% after 2006, following the implementation of national control policies; we tested two hypotheses to investigate their role in this decline. First, if C difficile infection declines in England were driven by reductions in use of particular antibiotics,...

artykuł

A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics

Katherine E. Beaney, Claire E. Ward, Dauda A. S. Bappa, Nadine McGale, więcej

Cardiovascular Diabetology > 2016 > 15 > 1 > 1-8

Background The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits. ...

artykuł

A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

Corneliu A. Bodea, Benjamin M. Neale, Stephan Ripke, Murray Barclay, więcej

The American Journal of Human Genetics > 2016 > 98 > 5 > 857-868

One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the vast set of benign variants. Risk variants are often sought by association studies in which allele frequencies in case subjects are contrasted with those from population-based samples used as control subjects. In an ideal world we would...

artykuł

Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3

Federico Oldoni, Jutta Palmen, Claudia Giambartolomei, Philip Howard, więcej

Atherosclerosis > 2016 > 246 > C > 193-201

Genome-wide association studies have confirmed the involvement of non-coding angiopoietin-like 3 (ANGPTL3) gene variants with coronary artery disease, levels of low-density lipoprotein cholesterol (LDL-C), triglycerides and ANGPTL3 mRNA transcript. Extensive linkage disequilibrium at the locus, however, has hindered efforts to identify the potential functional variants. Using regulatory annotations...

rozdział

Vortex Induced Oscillations of Cylinders at Low and Intermediate Reynolds Numbers

Roberto Camassa, Bong Jae Chung, Philip Howard, Richard McLaughlin, więcej

Advances in Mathematical Fluid Mechanics > 135-145

We study the orientational behavior of a hinged cylinder suspended in a water tunnel in the presence of an incompressible flow with Reynolds number (Re), based on particle dimensions, ranging between 100 and 6000 and non-dimensional inertia of the body(I *) in the range 0.1–0.6. The cylinder displays four unique features, which include: steady orientation, random oscillations, periodic oscillations...

artykuł

New guidelines for prevention and management of implantable cardiac electronic device-related infection

Jonathan A T Sandoe, Gavin Barlow, John B Chambers, Michael Gammage, więcej

The Lancet > 2015 > 385 > 9984 > 2225-2226

artykuł

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Daniel I Swerdlow, David Preiss, Karoline B Kuchenbaecker, Michael V Holmes, więcej

The Lancet > 2015 > 385 > 9965 > 351-361

Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. We used single nucleotide polymorphisms in the HMGCR gene, rs17238484 (for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins...

artykuł

Relationships Between Denial, Risk, and Recidivism in Sexual Offenders

Leigh Harkins, Philip Howard, Georgia Barnett, Helen Wakeling, więcej

Archives of Sexual Behavior > 2015 > 44 > 1 > 157-166

The aim of this study was to examine the relationship between denial, static risk, and sexual recidivism for offenders with different types of current sexual offense. Denial was defined as failure to accept responsibility for the current offense and was assessed using the Offender Assessment System. Static risk level (measured using a revised version of the Risk Matrix 2000) was examined as a moderator...

artykuł

Antimicrobial Stewardship from Policy to Practice: Experiences from UK Antimicrobial Pharmacists

Mark Gilchrist, Paul Wade, Diane Ashiru-Oredope, Philip Howard, więcej

Infectious Diseases and Therapy > 2015 > 4 > 1 > 51-64

Antimicrobial stewardship in the UK has evolved dramatically in the last 15 years. Factors driving this include initial central funding for specialist pharmacists and mandatory reductions in healthcare-associated infections (particularly Clostridium difficile infection). More recently, the introduction of national stewardship guidelines, and an increased focus on stewardship as part of the UK five-year...

artykuł

Antimicrobial Regime for Cardiac Surgery: The Safety and Effectiveness of Short‐Course Flucloxacillin (or Teicoplanin) and Gentamicin‐Based Prophylaxis

Ralph W. White, Robert West, Philip Howard, Jonathan Sandoe

Journal of Cardiac Surgery > 28 > 5 > 512 - 516

ObjectivesTo determine if changing from multidose cefuroxime‐based to flucloxacillin (or teicoplanin) and gentamicin‐based antibiotic prophylaxis for cardiac surgery was as effective at preventing infections without increasing postoperative renal impairment. MethodsOutcomes in consecutive patients from two 18‐month periods with the different antibiotic regimes. Group 1 (1725 patients)—cefuroxime...

artykuł

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

Philippa J Talmud, Sonia Shah, Ros Whittall, Marta Futema, więcej

The Lancet > 2013 > 381 > 9874 > 1293-1301

Familial hypercholesterolaemia is a common autosomal-dominant disorder caused by mutations in three known genes. DNA-based cascade testing is recommended by UK guidelines to identify affected relatives; however, about 60% of patients are mutation-negative. We assessed the hypothesis that familial hypercholesterolaemia can also be caused by an accumulation of common small-effect LDL-C-raising alleles...

artykuł

How long did it last? A 10-year reconviction follow-up study of high intensity training for young offenders

Darrick Jolliffe, David P. Farrington, Philip Howard

Journal of Experimental Criminology > 2013 > 9 > 4 > 515-531

Objectives Most research has suggested that correctional boot camps are not very successful in reducing reoffending, but recent evidence has been more encouraging for programs that include significant rehabilitative components. In line with this, High Intensity Training (HIT) for offenders aged 18–21 at Thorn Cross Young Offender Institution in England was followed by a significant reduction in the...

artykuł

Spectral Hounsfield units: a new radiological concept

Michael Anthony Hurrell, Anthony Philip Howard Butler, Nicholas James Cook, Philip Howard Butler, więcej

European Radiology > 2012 > 22 > 5 > 1008-1013

Objective Computed tomography (CT) uses radiographical density to depict different materials; although different elements have different absorption fingerprints across the range of diagnostic X-ray energies, this spectral absorption information is lost in conventional CT. The recent development of dual energy CT (DECT) allows extraction of this information to a useful but limited extent. However,...

artykuł

Category: Lesson in Microbiology & Infection Control

Jonathan Sandoe, Philip Howard, Abimbola Olusoga

Journal of Infection > 2011 > 63 > 6 > e97-e98

artykuł

Category: Lesson in Microbiology & Infection Control

Philip Howard, Helen Smith, Rob Child, Jason Dunne, więcej

Journal of Infection > 2011 > 63 > 6 > e96-e97

artykuł

Category: Lesson in Microbiology & Infection Control

Jonathan Sandoe, Philip Howard, Abimbola Olusoga, Katy Warburton

Journal of Infection > 2011 > 63 > 6 > e97

artykuł

Optimization of the Antitumor Activity of Sequence-specific Pyrrolobenzodiazepine Derivatives Based on their Affinity for ABC Transporters

Maciej Kaliszczak, Dyeison Antonow, Katan I. Patel, Philip Howard, więcej

The AAPS Journal > 2010 > 12 > 4 > 617-627

Pyrrolobenzodiazepine (PBD) derivatives are highly potent sequence-specific DNA cross-linking agents. The present study aimed to identify key physicochemical properties influencing the interaction of a series of PBDs (four dimers and 12 monomers) with the three major human ATP-binding cassette (ABC) transporters (P-gp, ABCG2, and MRP1). Isogenic cell lines expressing P-gp and ABCG2, cell lines with...

artykuł

Estimating biodegradation half-lives for use in chemical screening

Dallas Aronson, Robert Boethling, Philip Howard, William Stiteler

Chemosphere > 2006 > 63 > 11 > 1953-1960

Biodegradation half-lives are needed for many applications in chemical screening, but these data are not available for most chemicals. To address this, in phase one of this work we correlated the much more abundant ready and inherent biodegradation test data with measured half-lives for water and soil. In phase two, we explored the utility of the BIOWIN™ models (in EPI Suite™) and molecular fragments...

Poprzednia

Następna

Opcje filtrowania

Data publikacji

Ustaw własny zakres dat

INFONA - portal komunikacji naukowej

Wyniki wyszukiwania dla: Philip Howard

Dodaj adresata

Anulowanie wysłania wiadomości

Czy na pewno chcesz anulować wysłanie wiadomości?

Wyślij wiadomość

Opcje filtrowania

Data publikacji

Ustawianie zakresu dat

Podaj zakres dat dla filtrowania wyświetlonych wyników. Możesz podać datę początkową, końcową lub obie daty. Daty możesz wpisać ręcznie lub wybrać za pomocą kalendarza.

Typ publikacji

Słowa kluczowe

Zbiór danych

Czasopismo

Zgłaszanie błędu / nadużycia

Nieudane wysłanie zgłoszenia

Ułatwienia dostępu