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Osteoporosis is a frequent bone disease that mainly affects women after menopause. It is characterized by a decrease in bone mass and a deterioration of the micro-architecture which can lead to an increased risk of fracture. Ultrasound technologies provide an affordable mean to implement non invasive solutions to diagnostically assess the characteristics of the bone structure. In this work, we are...
Histopathological detection of metastases in dissected lymph nodes of cancer patients is critical to proper staging and management but current histological methods fail to detect small, but clinically-relevant, metastases. Quantitative ultrasound (QUS) permits characterization of tissue microstructure using system-independent estimates. In this study, more than 250 freshly-excised lymph nodes were...
High-frequency quantitative ultrasound (QUS) permits characterization of tissue microstructure using system-independent estimates. In this study, freshly-excised lymph nodes from cancer patients were evaluated using specifically designed three-dimensional (3D) QUS methods. The long-term objective was to develop 3D QUS methods for detecting metastases. Detection of metastases is critically important...
At the mesoscale (a few millimeters), cortical bone can be described as a two-phase material which consists in a relatively hard matrix and pores. The mesoscopic elastic properties are hence essentially determined by the stiffness of the matrix and the pores morphology. The goal of the study was to assess the relative contributions of tissue elasticity and porosity to mesoscopic elasticity. Measurements...
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