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Drug hypersensitivity reactions (DHRs) are a matter of great concern, both for outpatient and in hospital care. The evaluation of these patients is complex, because in vivo tests have a suboptimal sensitivity and can be time‐consuming, expensive and potentially risky, especially drug provocation tests. There are several currently available in vitro methods that can be classified into two main groups:...
Skin tests are of paramount importance for the evaluation of drug hypersensitivity reactions. Drug skin tests are often not carried out because of lack of concise information on specific test concentrations. The diagnosis of drug allergy is often based on history alone, which is an unreliable indicator of true hypersensitivity.To promote and standardize reproducible skin testing with safe and nonirritant...
Im letzten Jahrzehnt gab es große Fortschritte im Verständnis der Pathophysiologie Röntgenkontrastmittel-induzierter Unverträglichkeitsreaktionen. „Sofortreaktionen“ entwickeln sich innerhalb 1 h nach Gabe von Röntgenkontrastmitteln (RKM) unter dem Bild einer Anaphylaxie. Juckende Exantheme, die nach mehreren Tagen in Erscheinung treten, sind die häufigsten „Spätreaktionen“. Es gibt Hinweise auf eine...
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