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Background
To evaluate the efficacy of gabapentin at 20 mg/kg per day in the treatment of vincristine‐related neuropathic pain.
Procedure
Children aged 1‐18 years who developed vincristine‐induced neuropathy on a St Jude frontline acute lymphoblastic leukemia trial were prospectively enrolled on a randomized, double‐blind, placebo‐controlled, phase II trial with two treatment arms: gabapentin plus...
BackgroundImproved cure rates for childhood acute lymphoblastic leukemia (ALL) over the past 2 decades have allowed greater attention to patients' quality of life. Neuropathic pain (NP) is an unpleasant side effect of chemotherapeutic agents for leukemia, especially vincristine.
ProcedureWe retrospectively reviewed the records of 498 patients treated on a single protocol for ALL to investigate the...
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