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► We studied neurodevelopmental effect of decabromodiphenyl ether (DBDE) in rats. ► Rat offspring were maternally exposed to DBDE through diet. ► DBDE unchanged neuronal distribution in the hippocampal CA1. ► DBDE caused irreversible white matter hypoplasia targeting oligodendrocytes.
Pregnant Sprague–Dawley rats were given diet containing decabromodiphenyl ether (DBDE) either at 0, 10, 100, or 1000ppm from gestation day (GD) 10 until day 20 after delivery (PND 20). No significant alterations were observed in maternal and offspring reproductive parameters. At PND 20, serum triiodothyronine concentrations examined in males were slightly reduced at 1000ppm (84.2% of the control value),...
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