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Valproic acid (VPA) is an anticonvulsant drug with demonstrated efficacy in the treatment of mania. In the present study, we found that chronic exposure of rat C6 glioma cells to VPA induces a coordinate decrease in multiple components of the β-adrenergic receptor- (β-AR) coupled cyclic adenosine 3 -5 monophosphate (cAMP) generating system. Chronic VPA decreased the number of β-ARs in a time-...
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