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Background Henoch–Schönlein purpura nephritis (HSPN) is the most serious long-term complication of Henoch–Schönlein purpura and aberrant galactosylation of IgA1 plays a role in its development. However, the precise role of genetic factors contributing to the abnormal IgA1 galactosylation remains unknown. Methods In order to examine the effects of C1GALT1 gene encoding core 1 β1,3-galactosyltransferase,...
Henoch–Schönlein purpura (HSP) is a multifactorial inflammatory disease whose pathogenesis remains unknown. Pyrin encoded by the MEFV gene (NM_000243; OMIM 608107) is an important active member of the inflammasome and has been shown to affect the expression of many of the genes involved in immune and inflammatory responses. The aim of our study was to elucidate the possible roles of MEFV genetic variants...
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