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Phosphorothioate compounds are widely used in agriculture and public health for the control of unwanted pests. The phosphorothioate parathion was metabolised to the toxic metabolite paraoxon (0.0380.683nmol/min per mg protein) and p-nitrophenol (0.0232.10nmol/min per mg protein) by human liver microsomes (n=27) in an NADPH-dependent reaction. There was a significant correlation (P0.02) between nifedipine...
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