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Anticarcinogenicity in a long-term rodent bioassay is defined as a statistically significant decrease of a specific tumor type in a dosed group following chemical exposure. About 92% of chemicals tested by the National Toxicology Program prior to 1983 reveal at least one site with a significant (p≤ 0.05) tumor rate decrease in one or more tested groups, a result consistent with those of J. K. Haseman...
It has been suggested that the decreased tumor rates (anticarcinogenicity) commonly observed in the National Toxicology Program (NTP) rodent bioassays may be caused by compound-induced decreases in body weight or decreases in survival of treated animals. In this study, weight decrement and survival depression following chemical treatment was studied for those chemicals which induce site specific decreases...
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